※Packaging may vary depending on the shipping period.

Features of Megalis

Megalis is an ED treatment medication produced by Macleods Pharmaceuticals Ltd. in Mumbai, India.

Megalis features include minimal food interference and prolonged efficacy lasting up to 36 hours.

Each tablet is individually foil-packed for convenient portability.

While most overseas generic Cialis alternatives come in 20mg doses, Megalis offers 10mg tablets for lower-dose initiation therapy.

Megalis Composition

Tadalafil／10mg, 20mg

Cross-border Purchase of Megalis

All Megalis products sold on our site undergo regular ingredient verification by professional institutions to ensure safe international purchases.

As a generic version of Cialis, Megalis contains the same active ingredient - tadalafil.

While maintaining equivalent efficacy to Cialis, Megalis offers more cost-effective pricing.

Megalis is the preferred choice for consumers seeking high-value generic Cialis alternatives.

Efficacy of Megalis

The active ingredient tadalafil inhibits PDE5 enzyme activity that causes erectile dysfunction.

By blocking PDE5's inhibitory effects, it promotes vasodilation and improved blood flow, enhancing penile blood circulation during sexual stimulation to support erectile function.

Effectively supports erection initiation and maintenance during sexual activity.

Duration of Megalis Effects

Compared to other ED medications, Megalis offers the longest duration:


Individual responses may vary. Typically takes effect within 1 hour, reaching peak plasma concentration in 3 hours (consistent across all doses).

Difference Between 10mg and 20mg

Based on clinical trial data of the original brand Cialis:

	Insertion Success Rate	Intercourse Success Rate
5mg	72.1%	51.4%
10mg	81.1%	64.6%
20mg	82.1%	68.4%

Data shows 20mg outperforms 10mg in both success metrics.

Related Pages

Tadalafil Product Series
・Generic Cialis

Frequently Asked Questions

Optimal Timing

The correct way to take Megalis is on an empty stomach, 1 hour before sexual activity.

After the first dose, wait at least 24 hours before the next dose.

Although the effect can last up to 36 hours, you only need to wait 24 hours between doses.

Dosage Reference

If 10mg shows insufficient effect, increase to 20mg. Adjust dosage according to individual needs.

Some users take 2-3 times the recommended dose for stronger effects, but this does not enhance efficacy.
The maximum single dose per sexual encounter is 20mg.

For smaller-built individuals, 10mg may be sufficient.

Dietary Considerations

Tadalafil, Megalis' active ingredient, is less affected by food compared to other ED medications.

While meal timing isn't crucial, it doesn't mean food has no effect at all.

For optimal results, take after low-calorie meals or on an empty stomach.

Alcohol Interaction

Can be taken with alcohol, but vasodilation may accelerate intoxication. Avoid excessive drinking.

Contraindications

・Cardiovascular disease patients (heart/blood vessel disorders) who shouldn't engage in sexual activity

・Patients with severe liver dysfunction

・Hypotension patients or uncontrolled hypertension patients

・Those with history of stroke/cerebral hemorrhage or myocardial infarction within past 6 months

・Individuals allergic to tadalafil

※Strictly follow medical instructions when taking this medication.

Main Side Effects

The main side effects include decreased blood pressure due to vasodilation, eye congestion, facial flushing, heart palpitations, nasal congestion, etc.

These side effects are caused by the vasodilation effect and may alleviate as sexual desire increases and penile blood flow improves.

If symptoms are severe, discontinue use and consult a doctor.

Frequency of Side Effects

The reported side effects of the main ingredient, Tadalafil, include mild headache, hot flashes, indigestion, etc.

More than 1%	Less than 1%	Frequency Unknown
Indigestion・Headache	Heart palpitations・Hot flashes・Gastritis, etc.	Eye pain・Abdominal pain・Migraine, etc.

Special Symptoms

Special symptoms such as visual abnormalities may occur, including seeing objects as if through blue-tinted glasses or difficulty distinguishing between blue and green.

In most cases, these are temporary and not a cause for concern, but significant vision loss may indicate a risk of Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION).

If symptoms like sudden vision loss or impairment occur, consult an ophthalmologist immediately.

Additionally, if an erection lasts longer than 4 hours, there may be a risk of priapism.

If an erection persists for more than 4 hours, seek medical attention immediately.

※What is Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)?
It is a condition where the optic nerve cells are impaired or necrotic due to interrupted blood supply.
This condition is called ischemic optic neuropathy.
While the causal relationship is not fully understood, a weak correlation with ED medication use has been identified.

※What is Priapism?
Priapism, also known as persistent erection, is a condition where the penis remains erect for an extended period without returning to its normal state.
The main cause is believed to be damage to the arterial system within the penile corpus cavernosum.
If an erection lasts longer than 4 hours, seek medical treatment immediately.

Contraindications

Contraindicated drugs refer to medications that interact with Megalis and must not be taken concurrently.

・Nitrate drugs and NO donor drugs
(Nitroglycerin, Amyl Nitrite, Isosorbide Dinitrate)
Combined use may enhance blood pressure-lowering effects.

・sGC stimulators
(Riociguat)
Concurrent use may lead to excessively low blood pressure.

Precautions

Precautionary drugs refer to medications that require special attention when used with Megalis.

・Grapefruit (including juice)
Furanocoumarin components may inhibit metabolic enzyme activity in the body, delaying drug breakdown.
This could lead to excessive absorption of drug components, thereby increasing both efficacy and side effects.

・CYP3A4 inhibitors/inducers
Ritonavir, Saquinavir, Darunavir

・Antihypertensive drugs
Since Megalis itself has blood pressure-lowering effects, concurrent use with antihypertensives may cause temporary dizziness, unsteadiness upon standing, or other hypotensive symptoms.

・Store in a cool place away from direct sunlight and low humidity.

・Keep out of reach of children.

・Do not transfer to another container to avoid accidental ingestion or product deterioration.

・For remaining portions after dividing doses, store airtight and consume within 2 days.

・Do not consume or use products past their expiration date.

Macleods Pharma